Chest. 2012 Nov;142(5):1104-10.BACKGROUND:Bronchodilators are central to the symptomatic management of patients with COPD.Previous data have shown that inhaled indacaterol improved numerous clinical outcomes over placebo. METHODS:This systematic review explored the efficacy and safety of indacaterol in comparison with tiotropium or bid long-acting beta 2 -agonists (TD-LABAs) for treatment of moderate to severe COPD. [...]
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Bertalan Mesko,MD,PhD    Alzheimer's Disease Education & Referral Center  Colorectal Cancer Screen  CDC.gov  
 | In the 10 years since tiotropium was introduced into clinical practice,it has become the mainstay long-acting bronchodilator for maintenance treatment in Chronic Obstructive Pulmonary Disease (COPD). Multiple randomised controlled trials have demonstrated its efficacy as an intervention which improves lung function,quality of life,symptom control and exercise capacity,and reduces exacerbations in patients [...] Edward Kerwin,Jacques Hebert,Nicola Gallagher,Carmen Martin,Tim Overend,Vijay K.T. Alagappan,Yimeng Lu,Donald BanerjiNov 1,2012;40:1106-1114Original Articles:COPD Eur Respir J:Most-Read Full-Text Articles Most Viewed:NEJM Most Viewed Articles –Week Cochrane Database Syst Rev. 2012 Jul 11;7:CD009285.BACKGROUND:Tiotropium is an anticholinergic agent which has gained widespread acceptance as a once daily maintenance therapy for symptoms and exacerbations of stable chronic obstructive pulmonary disease (COPD). In the past few years there have been several systematic reviews of the efficacy of tiotropium,however,several new trials have [...] Thorax. 2012 Apr 27.BACKGROUND:Current guidelines recommend treatment with one or more long-acting bronchodilators for patients with moderate or more severe chronic obstructive pulmonary disease (COPD). The authors investigated the approach of dual bronchodilation using indacaterol,a once-daily long-acting beta(2) agonist,and the long-acting muscarinic antagonist tiotropium,compared with tiotropium alone. METHODS:In two identically [...] W. Vincken,J.A. van Noord,A.P.M. Greefhorst,Th.A. Bantje,S. Kesten,L. Korducki,P.J.G. CornelissenFeb 1,2002;19:209-216Original Articles:COPD/Respiratory Muscles Eur Respir J:Most-Cited Full-Text Articles R. Casaburi,D.A. Mahler,P.W. Jones,A. Wanner,G. San Pedro,R.L. ZuWallack,S.S. Menjoge,C.W. Serby,T. Witek JrFeb 1,2002;19:217-224Original Articles:COPD/Respiratory Muscles Eur Respir J:Most-Cited Full-Text Articles R. Casaburi,D.A. Mahler,P.W. Jones,A. Wanner,G. San Pedro,R.L. ZuWallack,S.S. Menjoge,C.W. Serby,T. Witek JrFeb 1,2002;19:217-224Original Articles:COPD/Respiratory Muscles Eur Respir J:Most-Cited Full-Text Articles D.E. O”Donnell,T. Fluge,F. Gerken,A. Hamilton,K. Webb,B. Aguilaniu,B. Make,H. MagnussenJun 1,2004;23:832-840Original Articles:COPD Eur Respir J:Most-Cited Full-Text Articles |
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