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Validation of a Cardiopulmonary Exercise Test Score in Heart Failure [Original Articles]

Background—

Cardiopulmonary exercise test (CPX) responses are strong predictors of outcomes in patients with heart failure. We recently developed a CPX score that integrated the additive prognostic information from CPX. The purpose of this study was to validate the score in a larger,independent sample of patients.

Methods and Results—

A total of 2625 [...]

Did the PREDIMED Trial Test a Mediterranean Diet?

Most Viewed:NEJM Most Viewed Articles –Week

Mayo Clinic Researchers Develop Test to Gauge Severity of Concussions

Neurologists at Mayo Clinic in Arizona have taken a promising step toward identifying a test that helps support the diagnosis of concussion. Mayo Clinic Research News and Discovery’s Edge

Empirical Evidence of the Importance of Comparative Studies of Diagnostic Test Accuracy

Background:

Systematic reviews that “compare” the accuracy of 2 or more tests often include different sets of studies for each test. Purpose:

To investigate the availability of direct comparative studies of test accuracy and to assess whether summary estimates of accuracy differ between meta-analyses of noncomparative and comparative studies. Data Sources:

Systematic reviews in [...]

Phase 1 ALS trial is first to test antisense treatment of neurodegenerative disease

The initial clinical trial of a novel approach to treating amyotrophic lateral sclerosis –blocking production of a mutant protein that causes an inherited form of the progressive neurodegenerative disease –may be a first step towards a new era in the treatment of such disorders. Mass General News Releases

Researchers Test Implanted Brain Stimulator for Alzheimer’s

Title:Researchers Test Implanted Brain Stimulator for Alzheimer’sCategory:Health NewsCreated:3/28/2013 12:35:00 PMLast Editorial Review:3/29/2013 12:00:00 AM MedicineNet Daily News

New blood test could identify early pancreatic cancer

An investigational serum biomarker panel accurately identified potentially resectable cases of pancreatic cancer,opening the possibility that a blood test could identify the cancer early and improve…

Surgery News

New Test Could Help Detect Pancreatic Cancer Early

A new diagnostic test that uses a scientific method called metabolomic analysis could help detect pancreatic cancer early,and therefore,improve the prognosis of patients with the disease. This new screening method is safe and easy,according to new research published in Cancer Epidemiology,Biomarkers,&Prevention,a journal of the American Association for Cancer [...]

The Clinical Utility of a Positive Antinuclear Antibody Test Result

Abstract:Background:This retrospective study investigated the clinical utility of a positive antinuclear antibody (ANA) test performed outside of the rheumatology setting. Prior studies have investigated the frequency of ANA positivity within the general population. The purpose of this investigation was to evaluate the clinical utility of a positive ANA test result in a real-world [...]

Breath Test Reveals Gut Bacteria Linked To Obesity

A growing body of evidence is increasingly showing us that the microbes in our gut influence our metabolism in surprising ways. Now a new study from the US suggests that a breath test of the gases they give out may indicate how susceptible a person is to developing obesity…Obesity / Weight Loss / [...]