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Pharmacomechanical Thrombolysis of Symptomatic Deep Vein Thrombosis

Division of Interventional Radiology

Interventional radiologists at Penn Medicine are performing pharmacomechanical thrombolysis in conjunction with catheter-directed thrombolytic therapy to manage symptomatic acute and subacute deep vein thrombosis (DVT). The goal of the therapy is to remove the majority of the clot burden with significantly less thrombolytic medication than conventional catheter-directed thrombolysis alone, thereby decreasing […]

Effects of the Oral Direct Renin Inhibitor Aliskiren in Patients With Symptomatic Heart Failure

John J.V. McMurray, Bertram Pitt, Roberto Latini, Aldo P. Maggioni, Scott D. Solomon, Deborah L. Keefe, Jessica Ford, Anil Verma, Jim Lewsey, for the Aliskiren Observation of Heart Failure Treatment (ALOFT) InvestigatorsMay 1, 2008; 1:17-24Original Article Circ Heart Fail: Most-Cited Full-Text Articles

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Prevalence and Outcomes of Symptomatic Intracranial Large Artery Stenoses and Occlusions in China: The Chinese Intracranial Atherosclerosis (CICAS) Study [Original Contribution]

Background and Purpose—

We aimed to establish the prevalence, characteristics, and outcomes of intracranial atherosclerosis (ICAS) in China by a large, prospective, multicenter study.


We evaluated 2864 consecutive patients who experienced an acute cerebral ischemia <7 days after symptom onset in 22 Chinese hospitals. All patients underwent magnetic resonance angiography, with measurement of diameter […]

Brain Natriuretic Peptide and Cardiac Resynchronization Therapy in Patients With Mildly Symptomatic Heart Failure [Original Articles]


There are limited data on the prognostic implications of brain natriuretic peptide (BNP) assessment in patients with mildly symptomatic heart failure (HF) who receive cardiac resynchronization therapy with a defibrillator (CRT-D).

Methods and Results—

The effect of elevated baseline and 1-year BNP levels (dichotomized at the upper tertile BNP of 120 pg/mL) on […]

Letter by Naylor Regarding Article, “Urgent Best Medical Therapy May Obviate the Need for Urgent Surgery in Patients With Symptomatic Carotid Stenosis” [Letter to the Editor]

Stroke ASAP

Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism

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An Overlooked Cause of Acute Symptomatic Seizures: Psychogenic Polydipsia

Metabolic encephalopathy and seizures are well-known serious manifestations of severe hyponatremia, because water equilibrates with cells leading to brain edema. Psychogenic polydipsia is a rare and often overlooked cause of hyponatremia, mostly described in the past in institutionalized patients with long-standing schizophrenia. However, psychogenic polydipsia has been observed recently in the community setting and outside […]

Effects of Phonophoresis of Piroxicam and Ultrasound on Symptomatic Knee Osteoarthritis

Abstract: Objective: To compare the effects of phonophoresis of piroxicam (PhP) and ultrasound therapy (UT) in patients with mild to moderate, symptomatic knee osteoarthritis (OA).Design: A randomized, double-blind, controlled trial.Setting: Department of rehabilitation medicine, university hospital.Participants: Patients with knee OA (N=46; mean age ± SD, 58.91±10.50y) who had visual analog scale (VAS) scores of 50 […]

Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)

Maxime Dougados, Karsten Kissel, Tom Sheeran, Paul P Tak, Philip G Conaghan, Emilio Martin Mola, Georg Schett, Howard Amital, Federico Navarro-Sarabia, Antony Hou, Corrado Bernasconi, TWJ HuizingaJan 1, 2013; 72:43-50Clinical and epidemiological research Ann. Rheum. Dis.: Most-Read Full-Text Articles

Characteristics of Ischemic Brain Lesions After Stenting or Endarterectomy for Symptomatic Carotid Artery Stenosis: Results From the International Carotid Stenting Study-Magnetic Resonance Imaging Substudy [Original Contributions]

Background and Purpose—

In a substudy of the International Carotid Stenting Study (ICSS), more patients had new ischemic brain lesions on diffusion-weighted magnetic resonance imaging (MRI) after stenting (CAS) than after endarterectomy (CEA). In the present analysis, we compared characteristics of diffusion-weighted MRI lesions.


Number, individual and total volumes, and location of new diffusion-weighted […]