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Fragile X Protein Linked to Nearly 100 Genes Involved in Autism

DURHAM,N.C. – Doctors have known for many years that patients with fragile X syndrome,the most common form of inherited intellectual disability,are often also diagnosed with autism. But little has been known about how the two diagnoses are related.

Now a collaborative research effort at Duke University Medical Center and Rockefeller University has [...]

Protein controlling glucose metabolism also a tumor suppressor

A protein known to regulate how cells process glucose also appears to be a tumor suppressor,adding to the potential that therapies directed at cellular metabolism may help suppress tumor growth. Mass General News Releases

Structure of the TatC core of the twin-arginine protein transport system

Nature advance online publication 02 December 2012. doi:10.1038/nature11683

Authors:Sarah E. Rollauer,Michael J. Tarry,James E. Graham,Mari Jääskeläinen,Franziska Jäger,Steven Johnson,Martin Krehenbrink,Sai-Man Liu,Michael J. Lukey,Julien Marcoux,Melanie A. McDowell,Fernanda Rodriguez,Pietro Roversi,Phillip J. Stansfeld,Carol V. Robinson,Mark S. P. Sansom,Tracy Palmer,Martin Högbom,[...]

Sudden Death in an Infant With Angina,Restrictive Cardiomyopathy,and Coronary Artery Bridging:An Unusual Phenotype for a{beta}-Myosin Heavy Chain (MYH7) Sarcomeric Protein Mutation [Images and Case Reports in Heart Failure]

Circulation:Heart Failure recent issues

Parkinson’s Disease Protein Causes Disease Spread and Neuron Death in Healthy Animals

After several years of incremental study,researchers at the Perelman School of Medicine,University of Pennsylvania have been able to piece together important steps in how Parkinson’s disease (PD) spreads from cell to cell and leads to nerve cell death.

Penn Medicine News

[...]

Parkinson’s Disease Protein Causes Disease Spread and Neuron Death in Healthy Animals

Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer’s disease. Now,after several years of incremental study,researchers at the Perelman School of Medicine,University of Pennsylvania have been able to piece together [...]

Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type 1 Receptor Protein [Original Article]

The angiotensin II type 1 receptor (AT1R) mediates most hypertensive actions of angiotensin II. To understand the molecular regulation of the AT1R in normal physiology and pathophysiology,methods for sensitive and specific detection of AT1R protein are required. Here,we examined the specificity of a panel of putative AT1R antibodies that are commonly used by [...]

IMMUNE REACTIVITY TO HEAT SHOCK PROTEIN 70 EXPRESSED IN THE KIDNEY IS CAUSE OF SALT SENSITIVE HYPERTENSION.

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One miR Level of Control:MicroRNA-155 Directly Regulates Endothelial Nitric Oxide Synthase mRNA and Protein Levels [Editorial Commentary]

Hypertension On-line First

Dietary management of chronic kidney disease:protein restriction and beyond.

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