Considerable progress has been made at the basic research level in our understanding of the molecular pathophysiology of myocarditis,as exemplified by the eloquent report of Weithauser et al. (1) in this issue of the Journal. Journal of the American College of Cardiology Current Issue
Giant-cell myocarditis often escapes diagnosis until autopsy or transplantation and has defied proper treatment trials for its rarity and deadly behavior. Current therapy rests on multiple-drug immunosuppression but its prognostic influence remains poorly known. We set out to analyze (1) our experience in diagnosing giant-cell myocarditis and (2) the outcome of patients on combined [...]
Abstract:Background:Mimicking ST-segment elevation myocardial infarction upon presentation,acute nonrheumatic streptococcal myocarditis is a treatable etiology of myocarditis which has only been infrequently reported.
Methods:Patients were identified through a retrospective query of electronic medical records over a 17-year period (January 1994 to December 2010). We describe a case series of acute nonrheumatic streptococcal [...]
Circulation:Heart Failure recent issues
Myocarditis is an inflammatory disease of the heart frequently resulting from viral infections and/or post-viral immune-mediated responses. It is one of the important causes of dilated cardiomyopathy worldwide. The diagnosis is presumed on clinical presentation and noninvasive diagnostic methods such as cardiovascular magnetic resonance imaging. Endomyocardial biopsy remains the gold standard for in vivo [...]