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Basic Research on Myocarditis Superb But Unrequited ∗

Considerable progress has been made at the basic research level in our understanding of the molecular pathophysiology of myocarditis, as exemplified by the eloquent report of Weithauser et al. (1) in this issue of the Journal. Journal of the American College of Cardiology Current Issue

Protease-Activated Receptor-2 Regulates the Innate Immune Response to Viral Infection in a Coxsackievirus B3–Induced Myocarditis


This study sought to evaluate the role of protease-activated receptor-2 (PAR2) in coxsackievirus B3 (CVB3)–induced myocarditis. Background

An infection with CVB3 leads to myocarditis. PAR2 modulates the innate immune response. Toll-like receptor-3 (TLR3) is crucial for the innate immune response by inducing the expression of the antiviral cytokine interferon-beta (IFNβ). Methods

To induce […]

Cardiac-Specific Overexpression of Melanoma Differentiation-Associated Gene-5 Protects Mice From Lethal Viral Myocarditis [Original Articles]


Viral myocarditis is among the most common causes of heart failure in children and young adults. The RNA helicase melanoma differentiation–associated gene-5 (MDA5) is critical for host antiviral responses against members of the Picornaviridae family, such as encephalomyocarditis virus (EMCV). MDA5-knockout mice are highly susceptible to EMCV infection and develop significant myocardial injury and […]

Diagnosis, Treatment, and Outcome of Giant-Cell Myocarditis in the Era of Combined Immunosuppression [Original Articles]


Giant-cell myocarditis often escapes diagnosis until autopsy or transplantation and has defied proper treatment trials for its rarity and deadly behavior. Current therapy rests on multiple-drug immunosuppression but its prognostic influence remains poorly known. We set out to analyze (1) our experience in diagnosing giant-cell myocarditis and (2) the outcome of patients on combined […]

Acute Nonrheumatic Streptococcal Myocarditis: STEMI Mimic in Young Adults

Abstract: Background: Mimicking ST-segment elevation myocardial infarction upon presentation, acute nonrheumatic streptococcal myocarditis is a treatable etiology of myocarditis which has only been infrequently reported.

Methods: Patients were identified through a retrospective query of electronic medical records over a 17-year period (January 1994 to December 2010). We describe a case series of acute nonrheumatic streptococcal […]

Myocarditis Associated With Campylobacter Enteritis: Report of Three Cases [Images and Case Reports in Heart Failure]

Circulation: Heart Failure recent issues

Update on Myocarditis

Myocarditis is an inflammatory disease of the heart frequently resulting from viral infections and/or post-viral immune-mediated responses. It is one of the important causes of dilated cardiomyopathy worldwide. The diagnosis is presumed on clinical presentation and noninvasive diagnostic methods such as cardiovascular magnetic resonance imaging. Endomyocardial biopsy remains the gold standard for in vivo […]