Nature Reviews Drug Discovery 12,346 (2013). doi:10.1038/nrd4020
Generating mouse models that have targeted genetic mutations currently relies on the use of targeting vectors and mutant embryonic stem cells (ESCs). Wefers et al. identified a new,quicker way of making mouse models of disease by microinjecting transcription activator-like effector nucleases (TALENs) [...]
We investigated the contribution of inositol(1,4,5)-trisphosphate (Ins(1,4,5)P3 [IP3]) receptors (IP3-R) to disease progression in mouse models of dilated cardiomyopathy (DCM) and pressure overload hypertrophy. Mice expressing mammalian sterile 20–like kinase and dominant-negative phosphatidylinositol-3-kinase in heart (Mst1xdn-PI3K-2Tg;DCM-2Tg) develop severe DCM and conduction block,associated with increased expression of type 2 IP3-R (IP3-R(2)) and heightened [...]
Background and Purpose—
The effect of flow diverter (FD) on hemodynamic changes observed in aneurysms is inevitably affected by the actual structural configuration of deployed FD. We studied the resultant hemodynamic changes after implantation of FDs using computational fluid dynamic simulations based on micro–computed tomography reconstructions in rabbit aneurysm model.
The FDs by micro–computed [...]
Objectives:This study examines the association between early-life socioeconomic status (SES) at age 18 and physical activity (PA) at age 65,elucidates mechanisms explaining this association,and explores gender differences in mediating pathways. Methods:Multigroup structural equation modeling is applied to the 1957 to 2004 data from the Wisconsin Longitudinal Study (WLS). Results:Early-life [...]
Patients with chronic kidney disease (CKD) are at increased risk for kidney failure,cardiovascular events,and all-cause mortality. Accurate models are needed to predict the individual risk for these outcomes. Purpose:
To systematically review risk prediction models for kidney failure,cardiovascular events,and death in patients with CKD. Data Sources:
MEDLINE search of [...]
Jordan Dolin,Co-Founder and Vice Chairman
Patient engagement is a critical element for all new models of care.
In order to bend the cost curve and ultimately transform the ailing U.S. healthcare system,organizations need to find more cost-effective ways to manage the health of large populations.
Regardless of whether it comes in [...]
Glucagon-Like Peptide-1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion,and has a range of metabolic effects including enhancing insulin secretion and decreasing food intake. Post-prandial GLP-1 secretion is greatly enhanced in rats and humans following some bariatric procedures,including Vertical Sleeve Gastrectomy (VSG),and has been [...]
Existing mouse models do not appear to accurately reproduce the human genomic response to serious traumatic injury,including major burns. Mass General News Releases
Treatment with a novel agent that inhibits the activity of SIRT2,an enzyme that regulates many important cellular functions,reduced neurological damage,slowed the loss of motor function and extended survival in two animal models of Huntington’s disease. Mass General News Releases