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Vitamin A isotope dilution predicts liver stores in line with long-term vitamin A intake above the current Recommended Dietary Allowance for young adult women [Vitamins,minerals,and phytochemicals]

Background:The Estimated Average Requirement (EAR) and Recommended Dietary Allowance (RDA) for vitamin A are 1.7 and 2.4 μmol/d (500 and 700 μg retinol activity equivalents/d),respectively,for nonpregnant,nonlactating women aged >19 y. This intake is presumed to maintain a minimally acceptable liver concentration of 0.07 μmol (20 μg) retinol/g;however,liver reserves have [...]

End of the line for PPAR modulators?

Nature Reviews Drug Discovery 12,568 (2013). doi:10.1038/nrd4098

Roche has terminated its development of aleglitazar,a dual peroxisome proliferator-activated receptor-α(PPARα) and PPARγagonist for type 2 diabetes.The lowdown:Roche pulled the plug on its programme for aleglitazar owing to the lack of efficacy and toxicity signals flagged by an independent

Nature [...]

NB4,a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

M Lanotte,V Martin-Thouvenin,S Najman,P Balerini,F Valensi,R BergerMar 1,1991;77:1080-1086ARTICLES Blood:Most-Cited Full-Text Articles

Primary Care Physicians are the First Line of Defense for Patients with the Holiday Blues

Barnes-Jewish Hospital –In the News

Benefit of Pulmonary Vein Isolation Guided by Loss of Pace Capture on the Ablation Line Results From a Prospective 2-Center Randomized Trial

Objectives

This study was conducted to determine if an additional procedural endpoint of unexcitability (UE) to pacing along the ablation line reduces recurrence of atrial fibrillation (AF) or atrial tachycardia (AT) after radiofrequency catheter ablation. Background

AF/AT recurrence is common after pulmonary vein isolation (PVI). Methods

We included 102 patients from 2 centers (age [...]

Joint Line Tenderness and McMurray Tests for the Detection of Meniscal Lesions:What Is Their Real Diagnostic Value?

Abstract:Objectives:To assess the interobserver concordance of the joint line tenderness (JLT) and McMurray tests,and to determine their diagnostic efficiency for the detection of meniscal lesions.Design:Prospective observational study.Setting:Orthopedics outpatient clinic,university hospital.Participants:Patients (N=60) with suspected nonacute meniscal lesions who underwent knee arthroscopy.Interventions:Not applicable.Main Outcome Measures:Patients were examined by [...]

Piperacillin and Tazobactam for Injection,USP 40.5 grams:Recall –Precipitation or Crystallization in IV Bag or IV Line Upon Reconstitution

Administration of precipitated Piperacillin/Tazobactam can lead to serious adverse events. MedWatch Safety Alert RSS Feed

New Balance Named as Presenting Sponsor of the Run to Home Base:Fans Race to Help Wounded Veterans –Fenway’s Famed Home Plate is Finish Line Run to Home Base Presented by New Balance

Local company teams up with Mass General and Red Sox Foundation to support veterans. Mass General News Releases

Out-of-Network Charges Out of Line with Medicare

(MedPage Today) —Out-of-network doctors sometimes charge several times more —often thousands of dollars more —than Medicare pays for the same service in the same area,according to a report from the leading health insurance industry group. MedPageToday.com –medical news plus CME for physicians

Technology for imaging can be for treatment too,but where’s the line between them?

On any given day thousands of patients around the world—children and adults—will get an x-ray. What they probably won’t think about while sitting on the table wearing one of those lead aprons,though,is how at that moment the same technology being used to take a picture of their arm or leg or skull [...]