JAMA. 2013 Apr 3;309(13):1368-78. doi:10.1001/jama.2013.3010.IMPORTANCE:Infections due to Staphylococcus aureus are serious complications of cardiothoracic surgery. A novel vaccine candidate (V710) containing the highly conserved S. aureus iron surface determinant B is immunogenic and generally well tolerated in volunteers. OBJECTIVE:To evaluate the efficacy and safety of preoperative vaccination in preventing serious postoperative S. [...]