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Bertalan Mesko,MD,PhD    Alzheimer's Disease Education & Referral Center  Colorectal Cancer Screen  CDC.gov  
 | Background and Purpose— A limited life expectancy reduces the benefit from carotid endarterectomy (CEA) for treatment of asymptomatic internal carotid artery stenosis. The aim of this study was to assess homocysteine as stratifying biomarker to improve prediction of postoperative survival. Methods— This was a prospective,nonrandomized case series from 2003 to 2012. Two hundred and [...] It is a commonly held perception that getting in shape and staying there requires hard work and hours upon hours of training. New research shows the opposite –it seems that only four minutes of vigorous activity three times per week is enough to be fit and healthy. Regular training improves maximal oxygen uptake (VO2max),[...] Abstract:Objective:To assess the effects of an unsupervised virtual reality (VR)-based exercise program on hip muscle strength and balance control in older adults.Design:Controlled cohort repeated-measures experimental design,a pilot study.Setting:University research laboratory.Participants:Ambulatory older adults (N=32) from a local community.Intervention:The VR group (n=18;mean ± SD,68.28±3.74y;4 men) completed the [...] Transgenic mice with endothelium-specific endothelin-1 (ET-1) overexpression exhibit endothelial dysfunction and vascular remodeling,oxidative stress,and inflammation. We previously observed that monocytes/macrophages play a role in angiotensin II,aldosterone,and deoxycorticosterone acetate/salt-induced vascular remodeling,oxidative stress,and inflammation using a model with reduced monocytes/macrophages,the osteopetrotic (Op) mouse,which has a mutation in the macrophage [...] Background— Heart failure is characterized by impaired function and disturbed Ca2+ homeostasis. Transgenic increases in inhibitor-1 activity have been shown to improve Ca2 cycling and preserve cardiac performance in the failing heart. The aim of this study was to evaluate the effect of activating the inhibitor (I-1c) of protein phosphatase 1 (I-1) through gene transfer [...] A new system for isolating rare circulating tumor cells –living solid tumor cells found at low levels in the bloodstream –shows significant improvement over previously developed devices and does not require prior identification of tumor-specific target molecules. Mass General News Releases Nature Reviews Cardiology 10,180 (2013). doi:10.1038/nrcardio.2013.25 Author:Gregory B. Lim Inhibition of angiotensin-converting enzyme (ACE) with ramipril as an adjunct to standard medical therapy increases both the maximum and the pain-free walking time of patients with peripheral artery disease (PAD). This finding comes from a randomized controlled trial conducted in Australia and published [...] Objective:To determine the effect of blood component ratios in massive transfusion (MT),we hypothesized that increased use of plasma and platelet to red blood cell (RBC) ratios would result in decreased early hemorrhagic death and this benefit would be sustained over the ensuing hospitalization. Summary Background Data:Civilian guidelines for massive transfusion (MT >=10 [...] |
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University of Washington - Seattle,WA --------------------------------------  --------------------------------------  University of Washington - Harborview Medical CenterSeattle,WA   Office on Women's Health U.S. Department of Health and Human Services      "Watch your weight & your waist!"     CDC:Public Health
  
 U.S. Department of Health & Human ServicesNational Health Information Center
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