Contractile | Knowledge of Medicine

Increased 99m Tc-Sestamibi Washout Reflects Impaired Myocardial Contractile and Relaxation Reserve During Dobutamine Stress Due to Mitochondrial Dysfunction in Dilated Cardiomyopathy Patients

Objectives

This study investigated whether the technitium-99m sestamibi (MIBI) washout rate (WR) would predict mitochondrial damage and myocardial dysfunction in patients with dilated cardiomyopathy (DCM). Background

Myocardial mitochondrial damage reduces adenosine triphosphate production,resulting in myocardial dysfunction. Increased myocardial 99mTc-MIBI washout is reportedly caused by mitochondrial dysfunction. Methods

Twenty DCM patients (New York Heart [...]

In Vivo Cardiac Myosin Binding Protein C Gene Transfer Rescues Myofilament Contractile Dysfunction in Cardiac Myosin Binding Protein C Null Mice [Original Articles]

Background—

Decreased expression of cardiac myosin binding protein C (cMyBPC) in the heart has been implicated as a consequence of mutations in cMyBPC that lead to abnormal contractile function at the myofilament level,thereby contributing to the development of hypertrophic cardiomyopathy in humans. It has not been established whether increasing the levels of cMyBPC in [...]

Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function [Original Articles]

Background—

Hypertrophic cardiomyopathy (HCM),typically characterized by asymmetrical left ventricular hypertrophy,frequently is caused by mutations in sarcomeric proteins. We studied if changes in sarcomeric properties in HCM depend on the underlying protein mutation.

Methods and Results—

Comparisons were made between cardiac samples from patients carrying a MYBPC3 mutation (MYBPC3mut;n=17),mutation negative HCM [...]

Relationship of MRI Delayed Contrast Enhancement to Irreversible Injury,Infarct Age,and Contractile Function

Raymond J. Kim,David S. Fieno,Todd B. Parrish,Kathleen Harris,Enn-Ling Chen,Orlando Simonetti,Jeffrey Bundy,J. Paul Finn,Francis J. Klocke,Robert M. JuddNov 9,1999;100:1992-2002Basic Science Reports Circulation:Most-Cited Full-Text Articles