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Cardiovascular event reduction versus new-onset diabetes during atorvastatin therapy:effect of baseline risk factors for diabetes.

J Am Coll Cardiol. 2013 Jan 15;61(2):148-52. doi:10.1016/j.jacc.2012.09.042. Epub 2012 Dec 5.OBJECTIVES:The purpose of this study was to compare the incidence of new-onset diabetes (NOD) with cardiovascular (CV) event reduction at different levels of NOD risk. BACKGROUND:Statins reduce the number of CV events but increase the incidence of NOD. We previously reported [...]

Maternal Cardiovascular Risk Profile After Placental Abruption [Original Article]

The prevalence of premature cardiovascular diseases (CVD) is increased in women with a history of maternal placental syndromes,including pregnancy-associated hypertensive disorders (eg,preeclampsia),fetal growth restriction,and placental abruption. Whereas previous studies have shown a high prevalence of CVD risk factors after pregnancies complicated by preeclampsia,this has not been studied for women with [...]

Cardiovascular disease:Secrets of an ageing heart

Nature Reviews Drug Discovery 12,264 (2013). doi:10.1038/nrd3987

Author:Charlotte Harrison

Ageing is a risk factor for cardiovascular disease. This study showed that microRNA-34a (miR-34a) expression is induced in the ageing mouse heart and contributes to the decline in cardiac function. Genetic inhibition of miR-34a reduced age- and myocardial infarction-associated cardiomyocyte death and fibrosis. [...]

Association of Epicardial Fat With Cardiovascular Risk Factors and Incident Myocardial Infarction in the General Population The Heinz Nixdorf Recall Study

Objectives

This study sought to determine whether epicardial fat volume predicts coronary events in the general population. Background

Epicardial adipose tissue (EAT) is suggested to promote plaque development in the coronary artery tree. Methods

We quantified EAT volume in participants from the prospective population-based Heinz Nixdorf Recall cohort study free of cardiovascular disease. Incident [...]

Electrocardiographic Abnormalities and Reclassification of Cardiovascular Risk:Insights from NHANES-III

Abstract:Background:We aimed to assess the additive value of electrocardiogram (ECG) findings to risk prediction models for cardiovascular disease.

Methods:Our dataset consisted of 6025 individuals with ECG data available from the National Health and Nutrition Examination Survey-III. This is a self-weighting sample with a follow-up of 79,046.84 person-years. The primary outcomes were cardiovascular [...]

A Blood Pressure Genetic Risk Score Is a Significant Predictor of Incident Cardiovascular Events in 32 669 Individuals [Original Article]

Recent genome-wide association studies have identified genetic variants associated with blood pressure (BP). We investigated whether genetic risk scores (GRSs) constructed of these variants would predict incident cardiovascular disease (CVD) events. We genotyped 32 common single nucleotide polymorphisms in several Finnish cohorts,with up to 32 669 individuals after exclusion of prevalent CVD cases. The [...]

Cost-Effectiveness of Statins for Primary Cardiovascular Prevention in Chronic Kidney Disease

Objectives

The authors sought to evaluate the cost-effectiveness of statins for primary prevention of myocardial infarction (MI) and stroke in patients with chronic kidney disease (CKD). Background

Patients with CKD have an elevated risk of MI and stroke. Although HMG Co-A reductase inhibitors (“statins”) may prevent cardiovascular events in patients with non–dialysis-requiring CKD,adverse [...]

Extreme Lipoprotein(a) Levels and Improved Cardiovascular Risk Prediction

Objectives

The study tested whether extreme lipoprotein(a) levels and/or corresponding LPA risk genotypes improve myocardial infarction (MI) and coronary heart disease (CHD) risk prediction beyond conventional risk factors. Background

Elevated lipoprotein(a) levels cause MI and CHD. Levels are primarily determined by variation in the LPA gene. Methods

We followed 8,720 Danish participants in a [...]

Overlap Between Common Genetic Polymorphisms Underpinning Kidney Traits and Cardiovascular Disease Phenotypes:The CKDGen Consortium.

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Association of a Change in Immunosuppressive Regimen with Hemodynamic and Inflammatory Markers of Cardiovascular Disease After Kidney Transplantation.

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