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Advances in the development of new tuberculosis drugs and treatment regimens

Nature Reviews Drug Discovery 12,388 (2013). doi:10.1038/nrd4001

Authors:Alimuddin Zumla,Payam Nahid &Stewart T. Cole

Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,rifampicin,pyrazinamide and ethambutol) treatment regimen,tuberculosis (TB) continues to cause considerable morbidity and mortality worldwide. For the first time since the 1960s,new [...]

Left Ventricular Dysfunction With Pulmonary Hypertension:Part 1:Epidemiology,Pathophysiology,and Definitions [Advances in Heart Failure]

Circulation:Heart Failure recent issues

Endothelin,Kidney Disease,and Hypertension [Recent Advances in Hypertension]

Hypertension On-line First

Meeting Announcement » Advances in Global Mental Health Research and Research Capacity Building Workshop

Meeting Announcement –Advances in Global Mental Health Research and Research Capacity Building Workshop NIMH | Recent Updates

Patterns of Disease Progression in Hypertrophic Cardiomyopathy:An Individualized Approach to Clinical Staging [Advances in Heart Failure]

Circulation:Heart Failure recent issues

Lost in Translation:Examining Patient and Physician Perceptions of Implantable Cardioverter-Defibrillator Deactivation Discussions [Advances in Heart Failure]

Circulation:Heart Failure recent issues

PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) Trial:Rationale and Design [Advances in Heart Failure]

Circulation:Heart Failure recent issues

New advances in the molecular study of diabetes

A new study describes for the first time the pharmacological action of thiazolidinediones (TZDs) —anti-diabetic drugs —directly on the pancreas,the organ which produces insulin. ScienceDaily:Obesity News

Advances in targeting cell surface signalling molecules for immune modulation

Nature Reviews Drug Discovery 12,130 (2013). doi:10.1038/nrd3877

Authors:Sheng Yao,Yuwen Zhu &Lieping Chen

The past decade has witnessed a surge in the development of immunomodulatory approaches to combat a broad range of human diseases,including cancer,viral infections,autoimmunity and inflammation as well as in the prevention of transplant rejection. Immunomodulatory [...]

Sympathetic Nervous System and Hypertension [Recent Advances in Hypertension]

Hypertension On-line First