Adverse events:Linking COX2 to cardiovascular side effects

Adverse events:Linking COX2 to cardiovascular side effects

Nature Reviews Drug Discovery 11,442 (2012).
doi:10.1038/nrd3766

Author:Charlotte Harrison

Anti-inflammatory inhibitors of cyclooxygenase 2 (COX2) have been shown to increase the risk of adverse cardiovascular events in clinical trials. This study showed that such adverse events could be due to COX2-induced suppression of prostaglandin I2 (PGI2) synthesis;PGI2

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