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Treatment of pulmonary hypertension in interstitial lung disease:do not throw out the baby with the bath water

Vincent CottinApr 1,2013;41:781-783 Eur Respir J:Most-Read Full-Text Articles

Systemic manifestations and comorbidities of COPD

P. J. Barnes,B. R. CelliMay 1,2009;33:1165-1185 Eur Respir J:Most-Cited Full-Text Articles

Alternatives to warfarin for the treatment of pulmonary emboli:the EINSTEIN-PE Study

The last few years have seen new oral anticoagulant treatments emerge with a major advantage over conventional vitamin K antagonism with warfarin:they have a predictable dose response that negates the need for laboratory monitoring. Dabigatran (Pradaxa),a direct thrombin inhibitor,and rivaroxaban are two such medications licenced for the prevention of stroke in atrial [...]

Another chemokine target bites the dust?

Scanning through the table of contents in Thorax,you might be forgiven for skipping over the paper by Wang et al.1 Redundancy in the chemokine field may not feel like news;however,I would suggest you pause and take time to read the article and perhaps reflect on a number of important issues that this [...]

Lung cancer survival and stage at diagnosis in Australia,Canada,Denmark,Norway,Sweden and the UK:a population-based study,2004-2007

Background

The authors consider whether differences in stage at diagnosis could explain the variation in lung cancer survival between six developed countries in 2004–2007.

Methods

Routinely collected population-based data were obtained on all adults (15–99 years) diagnosed with lung cancer in 2004–2007 and registered in regional and national cancer registries in Australia,Canada,Denmark,Norway,[...]

The 6-min walk distance in healthy subjects:reference standards from seven countries

C. Casanova,B.R. Celli,P. Barria,A. Casas,C. Cote,J.P. de Torres,J. Jardim,M.V. Lopez,J.M. Marin,M. Montes de Oca,V. Pinto-Plata,A. Aguirre-Jaime,on behalf of the Six Minute Walk Distance Project (ALAT)Jan 1,2011;37:150-156Original Articles:Lung Function Eur Respir J:Most-Read Full-Text Articles

Inhaled corticosteroids in COPD:quantifying risks and benefits

It is by no means straightforward to analyse the change in the rate of chronic obstructive pulmonary disease (COPD) exacerbations in clinical trials. Exacerbation rates do not follow a normal distribution,nor do they occur at random. High exacerbation rates in a few patients can make average rates difficult to calculate and interpret. So,[...]

Highlights from this issue

Spit it out?

What can we expect novel therapies to do for patients with cystic fibrosis (CF)? Everyone wants a cure,but how will we know if we have achieved it? Mortality is only applicable if Methuselah was the principle investigator,because survival curves are so flat. Horsley et al (see page 532) have [...]

Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis

T. Maron-Gutierrez,R.C. Castiglione,D.G. Xisto,M.G. Oliveira,F.F. Cruz,R. Pecanha,H. Carreira-Junior,D.S. Ornellas,M.O. Moraes,C.M. Takiya,P.R.M. Rocco,M.M. MoralesMay 1,2011;37:1217-1225Original Articles:Lung Cell Biology Eur Respir J:Most-Read Full-Text Articles

High-frequency oscillatory ventilation and acute respiratory distress syndrome:at the crossroads?

Acute respiratory distress syndrome (ARDS) was characterised by Ashbaugh and colleagues1 nearly half a century ago,and yet,to the casual observer,it might appear that little progress has been made since. Clinicians are still struggling with how best to define and treat ARDS.2 3 A major advance was the recognition that mechanical ventilation [...]