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Bertalan Mesko,MD,PhD    Alzheimer's Disease Education & Referral Center  Colorectal Cancer Screen  CDC.gov  
 | Background and Purpose— Recently,a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by promoting a small vessel arteriopathy,it might be expected to also associate with lacunar [...] Background and Purpose— Two randomized trials suggested that transcranial laser therapy (TLT) may benefit patients with acute ischemic stroke,although efficacy has not been confirmed. Supportive proof of concept could be demonstrated if TLT reduces the volume of cortical infarction. Methods— The NeuroThera Efficacy and Safety Trial-2 (NEST-2) was a randomized trial of TLT versus [...] Background and Purpose— Cerebrovascular and cardiovascular disease share common risk factors. Our goal was to determine whether levels of N-terminal brain natriuretic peptide (NT-proBNP) and cardiac troponin T measured with a highly sensitive assay (hs-cTnT) are associated with silent brain infarcts (BIs) and white matter lesions (WMLs) on MRI in the Atherosclerosis Risk in Communities [...] Background and Purpose— High blood pressure is common in the acute phase of stroke and is associated with poor outcome. We examined whether blood pressure–lowering treatment with candesartan in the acute phase affects long-term cognitive function and quality of life. Methods— Scandinavian Candesartan Acute Stroke Trial was a randomized-controlled and placebo-controlled trial of candesartan in [...] Background and Purpose— Reliable comparisons of stroke incidence are important. To determine the impact of systematic assessment of patients referred with transient ischemic attack on the measured incidence and severity of stroke,we compared 2 population-based studies. Methods— Patients with first-ever stroke ascertained during 2006 through 2010 from the Dijon Stroke Registry and the Oxford [...] Background and Purpose— Little research regarding genotypes and clopidogrel response related to acute ischemic stroke has been published. This study was conducted to investigate whether the polymorphisms of receptors or enzymes involved in the metabolic process of clopidogrel affect clopidogrel response and prognosis related to acute stroke. Methods— A total of 259 patients with acute [...] Background and Purpose— At 1.5 T,diffusion-weighted imaging–fluid-attenuated inversion recovery (DWI–FLAIR) mismatch helps identify strokes within 4.5 hours of onset. However,at 3T,studies have found divergent results. The goal of this study was to determine whether DWI–FLAIR mismatch at 3T would also be helpful for identifying patients within 4.5 hours of symptom onset. Methods—[...] Background and Purpose— The effect of flow diverter (FD) on hemodynamic changes observed in aneurysms is inevitably affected by the actual structural configuration of deployed FD. We studied the resultant hemodynamic changes after implantation of FDs using computational fluid dynamic simulations based on micro–computed tomography reconstructions in rabbit aneurysm model. Methods— The FDs by micro–computed [...] Background and Purpose— It is unknown whether supraventricular arrhythmias other than atrial fibrillation or flutter are associated with stroke. Methods— To examine the association between paroxysmal supraventricular tachycardia (PSVT) and stroke,we performed a retrospective cohort study using administrative claims data from all emergency department encounters and hospitalizations at California’s nonfederal acute care hospitals in [...] Background and Purpose— Treatment of acute hypertension after intracerebral hemorrhage (ICH) is controversial. In the context of disrupted cerebral autoregulation,blood pressure (BP) reduction may cause decreased cerebral blood flow (CBF). We used serial computed tomography perfusion to test the hypothesis that CBF remains stable after BP reduction. Methods— Patients recruited within 72 hours of [...] |
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University of Washington - Seattle,WA --------------------------------------  --------------------------------------  University of Washington - Harborview Medical CenterSeattle,WA   Office on Women's Health U.S. Department of Health and Human Services      "Watch your weight & your waist!"     CDC:Public Health
  
 U.S. Department of Health & Human ServicesNational Health Information Center
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