Transgenic mice with endothelium-specific endothelin-1 (ET-1) overexpression exhibit endothelial dysfunction and vascular remodeling,oxidative stress,and inflammation. We previously observed that monocytes/macrophages play a role in angiotensin II,aldosterone,and deoxycorticosterone acetate/salt-induced vascular remodeling,oxidative stress,and inflammation using a model with reduced monocytes/macrophages,the osteopetrotic (Op) mouse,which has a mutation in the macrophage [...]
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Bertalan Mesko,MD,PhD    Alzheimer's Disease Education & Referral Center  Colorectal Cancer Screen  CDC.gov  
 | Monoamine oxidases (MAOs) generate H2O2 as a by-product of their catalytic cycle. Whether MAOs are mediators of endothelial dysfunction is unknown and was determined here in the angiotensin II and lipopolysaccharide-models of vascular dysfunction in mice. Quantitative real-time polymerase chain reaction revealed that mouse aortas contain enzymes involved in catecholamine generation and MAO-A and MAO-B [...] Proinflammatory cytokines play an important role in regulating autonomic and cardiovascular function in hypertension and heart failure. Peripherally administered proinflammatory cytokines,such as tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β),act on the brain to increase blood pressure,heart rate,and sympathetic nerve activity. These molecules are too large to penetrate the blood–brain barrier,and [...] Aortic stiffness is associated with increased cardiovascular mortality in patients with chronic kidney disease. However,the rate of progression of arterial stiffness and the role of cardiovascular risk factors in the progression of arterial stiffness has never been established in a longitudinal study. In a prospective,longitudinal,observational study,carotid-femoral pulse wave velocity and carotid-radial [...] Primary aldosteronism (PA),a common cause of high blood pressure (BP),induces left ventricular (LV) hypertrophy and an excess rate of cardiovascular events. Whether its treatment provides long-term cure of hypertension and regression of cardiovascular damage remains uncertain. To the aim of assessing the effect of treatment of PA on BP and LV changes,we [...] The angiotensinogen gene is genetically linked with hypertension,but the mechanistic basis for association of sequence variants in the promoter and coding region of the gene remains unclear. An E-box at position –20 has been hypothesized to control the level of angiotensinogen expression,but its mechanistic importance for angiotensinogen expression in human tissues is uncertain. [...] |
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University of Washington - Seattle,WA --------------------------------------  --------------------------------------  University of Washington - Harborview Medical CenterSeattle,WA   Office on Women's Health U.S. Department of Health and Human Services      "Watch your weight & your waist!"     CDC:Public Health
  
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