Circulation:Heart Failure recent issues
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Bertalan Mesko,MD,PhD    Alzheimer's Disease Education & Referral Center  Colorectal Cancer Screen  CDC.gov  
 | Circulation:Heart Failure recent issues Circulation:Heart Failure recent issues Background— Tumor necrosis factor-αand other proinflammatory cytokines activate the canonical Nuclear Factor (NF)-B pathway through the kinase IKKβ. Previously,we established that IKKβis also critical for Akt-mediated NF-B activation in ventricular myocytes. Akt activates the kinase mammalian target of rapamycin (mTOR),which mediates important processes such as cardiac hypertrophy. However,whether mTOR regulates [...] Background— We investigated the contribution of inositol(1,4,5)-trisphosphate (Ins(1,4,5)P3 [IP3]) receptors (IP3-R) to disease progression in mouse models of dilated cardiomyopathy (DCM) and pressure overload hypertrophy. Mice expressing mammalian sterile 20–like kinase and dominant-negative phosphatidylinositol-3-kinase in heart (Mst1xdn-PI3K-2Tg;DCM-2Tg) develop severe DCM and conduction block,associated with increased expression of type 2 IP3-R (IP3-R(2)) and heightened [...] Alexander R. Lyon,Viacheslav O. Nikolaev,Michele Miragoli,Markus B. Sikkel,Helen Paur,Ludovic Benard,Jean-Sebastien Hulot,Erik Kohlbrenner,Roger J. Hajjar,Nicholas S. Peters,Yuri E. Korchev,Ken T. Macleod,Sian E. Harding,Julia GorelikMay 1,2012;5:357-365 Circ Heart Fail:Most-Cited Full-Text Articles Background— Heart failure is characterized by impaired function and disturbed Ca2+ homeostasis. Transgenic increases in inhibitor-1 activity have been shown to improve Ca2 cycling and preserve cardiac performance in the failing heart. The aim of this study was to evaluate the effect of activating the inhibitor (I-1c) of protein phosphatase 1 (I-1) through gene transfer [...] Background— Despite a national organ-donor shortage and a growing population of patients with end-stage heart disease,the acceptance rate of donor hearts for transplantation is low. We sought to identify donor predictors of allograft nonuse,and to determine whether these predictors are in fact associated with adverse recipient post-transplant outcomes. Methods and Results— We [...] |
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