Atrial fibrillation (AF) is the most common arrhythmia and is associated with a high risk of stroke and an increased risk of death (1). Although an association between AF and inflammation is now well established,the cause-and-effect relationship remains incompletely understood (2,3). Previous studies have demonstrated that increased inflammation may precede AF (4,5),supported by evidence that genetic variants related to inflammatory processes may be more prevalent in AF patients (6,7). Conversely,we and others have shown that AF itself may contribute to an inflammatory state (8,9,10,11).
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