Herbicide Roundup Intoxication:Successful Treatment with Continuous Renal Replacement Therapy

Roundup (Monsanto Corporation,St. Louis,Mo) is a commercial herbicide containing glyphosate and surfactant,used primarily for killing weeds. Its key component,glyphosate,is a competitive inhibitor of the shikimate pathway,a metabolic pathway found only in plants. However,serious intoxication,including lethal cases by ingestion of Roundup,has been reported,with a mortality rate of 7%-30%. We describe a patient with a near-lethal case of Roundup intoxication with multiorgan system failure who recovered after continuous renal replacement therapy.
The American Journal of Medicine

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