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Welcome

Smart medicine is better health.

Welcome to Knowledge of Medicine –your internet resource for everything medicine. We provide the best health/medical resources available on the internet for both the professional and patient communities. Our comprehensive searches and selection of those medical internet sites with extraordinary content are provided as educational and informational tools. Medical care delivery must be educational,participatory and collaborative with all health partners. Take charge of your medical knowledge –only you can do it!

Harlan R. Weinberg,MD,FCCP

Educate –Participate –Communicate

Official NHS health information

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Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome

Apoptosis signal-regulating kinase 1 (ASK1) is activated by various stresses. The link between ASK1 activation and endoplasmic reticulum (ER) stress,two causal events in diabetic embryopathy,has not been determined. We sought to investigate whether ASK1 is involved in the unfolded protein response (UPR) that leads to ER stress. Deleting Ask1 abrogated diabetes-induced UPR by suppressing phosphorylation of inositol-requiring enzyme 1 alpha (IRE1α) and double stranded RNA activated protein kinase (PKR)-like ER kinase (PERK),blocked the mitochondrial translocation of proapoptotic Bcl-2 members and ER stress. ASK1 participated in the IRE1αsignalosome,and removing ASK1 abrogated the proapoptotic kinase activity of IRE1α. Ask1 deletion suppressed diabetes-induced IRE1αendoriboneclease activities,which led to X-box binding protein 1 mRNA cleavage,an ER stress marker;decreased expression of microRNAs;and increased expression of a miR-17 target,thioredoxin-interacting protein (Txnip),a thioredoxin binding protein,which enhanced ASK1 activation by disrupting the thioredoxin-ASK1 complexes. ASK1 is essential for the assembly and function of the IRE1αsignalosome,which forms a positive feedback loop with ASK1 through Txnip. ASK1 knockdown in C17.2 neural stem cells diminished high glucose- or tunicamycin-induced IRE1αactivation,which further supports our hypothesis that ASK1 plays a causal role in diabetes-induced ER stress and apoptosis.

Diabetes Journal publish ahead of print articles

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Anaesthetists’Non-Technical Skills (ANTS):evaluation of a behavioural marker system{dagger}

G. Fletcher,R. Flin,P. McGeorge,R. Glavin,N. Maran,R. Patey
May 1,2003;90:580-588
Clinical Investigation
Br J Anaesth:Most-Cited Full-Text Articles

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Pharmacy Creations Certain Products:Recall – Potential Non-Sterility

Compromised sterility of a product may lead to risk for infection
MedWatch Safety Alert RSS Feed

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An insider’s guide to MD Anderson

Mays_Clinic_fountain_411_SkyKMCropFlat.jpgIt can take a while to learn all the ins and outs of MD Anderson. To help you get ahead and make your next trip to MD Anderson even better,we’re sharing our insider tips.

Grab free coffee while visiting a Hospitality Center. 
Coffee is available in the cafeterias and the various coffee shops throughout campus,but you can find free coffee in our Hospitality Centers in the Main Building and Mays Clinic. Stop by and chat with our volunteers. Many of them are members of the Anderson Network and are cancer survivors themselves.

Find our Hospitality Centers.

Leave the babysitting to us.
Our Child Visitation Rooms offers free,safe,short-term child care of children ages 2 months to 12 years. Drop your kids off for up to two hours at a time,so they can play with toys and games or watch movies while you tend to the business of cancer.
Just make sure that your kids are in good health and up-to-date on their vaccinations before bringing them.

Learn more about our Child Visitation Rooms.

Drop off your luggage.
Don’t have time to check in at the hotel before your appointments? Or,don’t have a place to leave your luggage before you return home? We can store it for you,so you don’t have to carry it around from appointment to appointment.

Simply drop off your luggage at one of our information desks located in the fronts of the Mays Clinic and the Main Building,so you don’t have to carry it around from appointment to appointment with you.

Mail a letter.
Did you know that MD Anderson has its own post office? Located on the first floor of the Main Building near elevator E,our post office ensures that more than 268,000 pieces of mail each month are transported and received.

It also sells postage stamps and provides special mailing services,such as certified/return receipt,insured,registered mail and speedy shipping services.

If the post office isn’t open,you can still buy stamps using our self-service kiosk at the post office.

Download the MD Anderson mobile app.

You don’t have to print your appointment schedule. Simply download the download the MD Anderson mobile app on your smartphone or tablet,and log in. The app also provides you with step-by-step directions to appointments,an events calendar,articles about the latest in cancer treatment and more.

Don’t have a smartphone or tablet? You can get a printout of your appointment schedule at any of our Information Centers in Mays Clinic or the Main Building. Find an Information Center.

Pick up a book.
Our Volunteer Services program hosts a library on the first floor of Main Building that offers books,magazines,newspapers and audio cassettes and tape recorders to keep you occupied.

You also can learn more about cancer treatment by visiting any of our three Learning Center locations.

Find a Learning Center location.


Do your laundry.

Need to do your laundry? We’ve got coin-operated washer-dryer facilities are available in the Main Building,floor 6,near elevator F. It’s open 24 hours a day. Laundry detergent can be purchased in the gift shops.

Relax and unwind.

Acupuncture and massages have both been shown to ease pain and help cancer patients relax. Both are available through our Integrative Medicine Center. To request an appointment,call 713-794-4700 or ask your MD Anderson doctor or nurse to submit a request for you.

Update your look.

Whether your hair has fallen out or you want to style new hair that’s coming in,our Beauty &Barber Shop can help. The shop,which is run by volunteers who understand what our patients are going through,provides shampoos,haircuts,shaves,wigs,scarves and hats. This service is provided at no cost to our patients on a first-come,first-served basis.

You can find the beauty &Barber Shop in the Main Building,floor 6,near elevator F. Learn more.

For more insider tips,read our Guide to MD Anderson.

Cancerwise | Cancer blog from MD Anderson Cancer Center

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EARLY RELEASE:Ebola Virus Disease Outbreak — West Africa,September 2014

Morbidity and Mortality Weekly Report (MMWR)

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Sterile Drug Products by Downing Labs (aka NuVision Pharmacy):Drug Alert –Lack of Sterility Assurance

UPDATED 09/09/2014. FDA has issued a formal request to Downing Labs for the immediate recall of all lots of its purportedly sterile products currently on the market that are not expired.
MedWatch Safety Alert RSS Feed

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Coping with physical changes after sarcoma surgery

KristineKeeney.jpgBy Kristine Keeney

When the doctors first told me about the details of my surgery for my sarcoma of the tongue,I couldn’t have imagined how much the surgical incisions would cause the injured tissues to swell or that the graft site on my left arm would end up looking like something out of a bad Halloween horror story.

In order to remove the sarcoma,doctors had to perform a full neck dissection and a resection of the floor of my mouth and part of my tongue. Then they rebuilt these parts with skin grafts from my left thigh and my arm.

Life after sarcoma surgery

The first time I saw my arm unwrapped,I was appalled. There was this huge swollen slab of me attached to my forearm,and it looked like it was either going to fall off or explode. I was actually afraid of my arm. I didn’t want to look at it or have anything to do with it. It bothered me,was the embodiment of nightmares,and made me feel like a freak.
Over the next few months,my arm started to heal. Those initial impressions,though,proved to be lasting. I still didn’t want to acknowledge that a part of my body was not as it should be. I was OK with the site on my thigh from which the doctors pulled the skin graft. I was OK with the scars and inflammation in my neck and jaw. I could see how everything was healing the way it should. I just couldn’t accept this one part of the surgery —the dent that was the result of various tissues,a section of vein and a section of artery that was taken out of my arm and the skin layer that covered the space left behind.

I spent a lot of time talking with Erin Buck,Ph.D.,a behavioral psychologist in MD Anderson’s Body Image Therapy Service,who helped me come to terms with all of the changes that all of my cancer treatments had left behind as marks on my body. In time,I came to accept my left arm and to actually take pride in how well and completely it had healed.

No longer hiding
These days,I no longer feel a need to cover it with long sleeves,carefully draped shawls,or elbow length fingerless gloves. I can get about the business of being the wonderful and beautiful unique person that I am.

I have a few very visible scars on my body. I see no reason to go out of my way to hide them or to display them. They are a part of me,as much as my hair color or my feet. My arm went from being a nightmare to being just another interesting thing.

I tell those curious people who ask about my left arm what happened,but I also tell them that I am proud of my arm. Part of my arm is now part of my tongue,and keeps me able to talk and eat. And part of my leg is now really part of my arm. Life is full of surprises.

That’s what part of loving yourself after dealing with cancer is about —finding the surprises,the good things in everyday life —and celebrating those changes,differences and remarkable miracles.

Kristine Keeney is participating in MD Anderson’s “Love Your Body Day”fashion show on Wednesday,Oct. 8,2014. For more information about Love Your Body Day or the Body Image Therapy Program,call 713-563-8032.

Cancerwise | Cancer blog from MD Anderson Cancer Center

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Announcements:World Rabies Day — September 28,2014

Morbidity and Mortality Weekly Report (MMWR)

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Announcements:World Heart Day — September 29,2014

Morbidity and Mortality Weekly Report (MMWR)

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Vaccination with Tetanus,Diphtheria,and Acellular Pertussis Vaccine of Pregnant Women Enrolled in Medicaid — Michigan,2011–2013

Morbidity and Mortality Weekly Report (MMWR)

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