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Welcome

Smart medicine is better health.

Welcome to Knowledge of Medicine –your internet resource for everything medicine. We provide the best health/medical resources available on the internet for both the professional and patient communities. Our comprehensive searches and selection of those medical internet sites with extraordinary content are provided as educational and informational tools. Medical care delivery must be educational,participatory and collaborative with all health partners. Take charge of your medical knowledge –only you can do it!

Harlan R. Weinberg,MD,FCCP

Educate –Participate –Communicate

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UofL Featured in Upcoming KET Special Report on Parenting

Newswise imageA pediatrician and nursing director of the Center for Women &Infants at the University of Louisville are interviewed on raising emotionally healthy children.
Newswise:MedNews

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Uncommon Genetic Variations May Contribute to Ovarian Cancer Risk

Variations in a woman’s genome may contribute to her risk of developing ovarian cancer. Researchers using data collected by the Ovarian Cancer Association Consortium have discovered uncommon variants in new regions of the genome that influence ovarian cancer risk,and will present their findings on April 6,2014 at the American Association for Cancer Research Annual Meeting in San Diego,CA.
Newswise:MedNews

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Roswell Park to Present Findings on Jasco Pharmaceuticals’Novel PIM Inhibitor at AACR 2014

Newswise imageRoswell Park will present findings from 3 studies of Jasco Pharmaceuticals’s JP_11646 at the AACR Annual Meeting 2014. The results show that the novel PIM inhibitor shows promise for treating pancreatic cancer,bladder cancer and acute leukemias.
Newswise:MedNews

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[Comment] Tuberculosis control needs a complete and patient-centric solution

Whether it is mobile phone service or vacation travel,good businesses know that success depends on providing a complete and customer-centric solution. Should patients with tuberculosis not be offered a complete solution that is patient-centred? After all,millions are affected and a large market at the base-of-the-pyramid remains unserved.
The Lancet Global Health

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Effect of Antispastic Drugs on Motor Reflexes and Voluntary Muscle Contraction in Incomplete Spinal Cord Injury

Abstract:Objective:To investigate the effects of antispastic drugs baclofen and tizanidine on reflexes and volitional tasks.Design:Double-blind,placebo-controlled,crossover,before-after trial,pilot study.Setting:Research laboratory in a rehabilitation hospital.Participants:Men with chronic (>6mo) motor incomplete spinal cord injury (N=10) were recruited for the study.Interventions:Tizanidine,baclofen,and placebo were tested in this study. Agents were tested in separate experimental sessions separated by >1 week.Main Outcome Measures:Reflex and strength were measured before and after the administration of a single dose of each intervention agent. Electromyographic and joint torque data were collected during assessments of plantar flexor stretch reflexes,maximum contraction during motor-assisted isokinetic movements,and maximum isometric knee extension and flexion.Results:Reduced stretch reflex activity was observed after the administration of either tizanidine or baclofen. We observed that tizanidine had a stronger inhibitory effect on knee extensors and plantar flexors whereas baclofen had a stronger inhibitory effect on the knee flexors. The effects of these drugs on strength during isometric and isokinetic tasks varied across participants,without a consistent reduction in torque output despite decreased electromyographic activity.Conclusions:These results suggest that antispastic drugs are effective in reducing stretch reflexes without substantially reducing volitional torque. Differential effects of tizanidine and baclofen on reflexes of flexors and extensors warrant further investigation into patient-specific management of antispastic drugs.
Archives of Physical Medicine and Rehabilitation

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Rehabilitation in ICU could improve quality of life long after discharge

After a stay in an intensive care unit (ICU),patients have substantial physical impairments even two years after being discharged from the hospital new Johns Hopkins research suggests.The scientists found that for every day of bed rest in the ICU,muscle strength was between 3 and 11 percent lower over the following months and years.
Rehabilitation / Physical Therapy News From Medical News Today

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Dolce far niente – It is sweet doing nothing

American Journal of Medicine,The

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Yield of Downstream Tests After Exercise Treadmill Testing A Prospective Cohort Study

Objectives

The purpose of this study was to estimate the frequency and results of downstream testing after exercise treadmill tests (ETTs).

Background

The utility of additional diagnostic testing after ETT is not well characterized.

Methods

We followed consecutive individuals without known coronary artery disease referred for clinical ETT at a large medical center. We measured the frequency and results of downstream imaging tests and invasive angiography within 6 months of ETT and the combined endpoint of survival free from cardiovascular death,myocardial infarction,and coronary revascularization.

Results

Among 3,656 consecutive subjects who were followed for a mean of 2.5 ± 1.1 years,332 (9.0%) underwent noninvasive imaging and 84 (2.3%) were referred directly to invasive angiography after ETT. The combined endpoint occurred in 76 (2.2%) patients. The annual incidence of the combined endpoint after negative,inconclusive,and positive ETT was 0.2%,1.3%,and 12.4%,respectively (p < 0.001). Rapid recovery of electrocardiography (ECG) changes during ETT was associated with negative downstream test results and excellent prognosis,whereas typical angina despite negative ECG was associated with positive downstream tests and adverse prognosis (p < 0.001). Younger age,female sex,higher metabolic equivalents of task achieved,and rapid recovery of ECG changes were predictors of negative downstream tests.

Conclusions

Among patients referred for additional testing after ETT,the lowest yield was observed among individuals with rapid recovery of ECG changes or negative ETT,whereas the highest yield was observed among those with typical angina despite negative ECG or a positive ETT. These findings may be used to identify patients who are most and least likely to benefit from additional testing.
Journal of the American College of Cardiology Current Issue

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Brigham and Women’s Hospital Featured as Part of Health Equity Research Snapshot

Brigham and Women’s Hospital has been featured in a Health Equity Research Snapshot by the Association of American Medical Colleges.
BWH News

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Sun-filled mornings may help us control our waistlines,say researchers

Could light be used as a tool to fight obesity? Researchers at Northwestern University in Evanston,IL,seem to think so. They publish their findings in PLOS One.The benefits of sunlight on human health are well documented. As well as providing us with necessary vitamin D,exposure to sunlight has also been implicated in preventing infectious disease and even lowering blood pressure.
Obesity / Weight Loss / Fitness News From Medical News Today

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