SHOTS -NPR's Health Blog
ZocDoc
ZocDoc
ZocDoc
-----------------------------
NY Organ Donor Network
Making Health Care Safer
Smoking causes immediate damage
Get Smart for Healthcare
Centers for Disease Control and Prevention (CDC)

eHealth Topics

Donate Life America

Bertalan Mesko,MD,PhD
Editor-in-Chief

CDC.gov
CDC.gov

Alzheimer's Disease Education & Referral Center

Colorectal Cancer Screen
Adult Smoking
CDC.gov
Child Safety Network

Healthy Environment,Healthy Kids

NRC Widget

Welcome

Smart medicine is better health.

Welcome to Knowledge of Medicine –your internet resource for everything medicine. We provide the best health/medical resources available on the internet for both the professional and patient communities. Our comprehensive searches and selection of those medical internet sites with extraordinary content are provided as educational and informational tools. Medical care delivery must be educational,participatory and collaborative with all health partners. Take charge of your medical knowledge –only you can do it!

Harlan R. Weinberg,MD,FCCP

Educate –Participate –Communicate

Official NHS health information

Audio clip:Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

Be Sociable,Share!

Oregon Compounding Centers,Inc. Unexpired Sterile Products:Recall –Lack of Sterility Assurance

Patients in Oregon and Washington may be at risk of serious infections which may be life threatening.
MedWatch Safety Alert RSS Feed

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

Notifiable Diseases and Mortality Tables

Morbidity and Mortality Weekly Report (MMWR)

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

Coping with leukemia and lymphoma in my 20s

laurengraham1022.jpgBy Lauren Graham

At age 20,I never imagined that I would have cancer. I was just figuring out what I wanted to do with my life:I’d decided to be a nurse.

But life handed me something completely different —a leukemia diagnosis and a lymphoma diagnosis.  

My dual diagnosis:T-cell acute lymphoblastic lymphoma and acute lymphoblastic leukemia
I had a swollen lymph node on my neck for over a month,but I never really though anything of it. I finished off a round of antibiotics,and my doctor told me to watch it and come back if anything new presented. About two weeks later,I woke up with 11 new swollen lymph nodes. 

After a couple of biopsies,doctors diagnosed me with stage 4 T-cell acute lymphoblastic lymphoma

At the time,I mentally blocked out my lymphoma diagnosis. I didn’t really believe that I had cancer because I didn’t feel sick. To be honest,I felt I didn’t have the time to deal with something as big as cancer and the possibility of chemotherapy. I began my treatment at MD Anderson where I found out my cancer had spread to my bone marrow. I also received a second diagnosis —acute lymphoblastic leukemia (ALL).
I went through nine months of aggressive chemotherapy,followed by two years of maintenance chemo.

I was so weak at the time. Some days it took everything I had to get up and ride in the car to MD Anderson. Some days were better than others. On a good day,I was able to ride the skybridge cart without wanting to throw up. 

Facing cancer as a young adult
I didn’t know ANYBODY my age with cancer. I tried to find books,articles,anything that would help me better understand what I was going through. I spent a lot of time journaling my feelings. Writing down what I was dealing with enabled me to process what was happening to me.

There was so much I didn’t know about cancer. I didn’t know that I would lose my eyebrows,eyelashes,and hair during chemo. Imagine my shock when I tried to apply mascara and ended up with half of my eyelashes on the mascara brush. 

Thankfully,I went into remission fairly quickly after starting chemo. I’m also fortunate that I went back to my doctor when I first noticed the swollen nodes. I’ve been told that if I had waited just a few weeks longer,I may not still be here. During my lymphoma and leukemia treatment,I took one semester off and slowly got back into the groove of taking college classes. I managed to earn a bachelor’s degree in liberal arts and communication. After finishing that degree,I started working toward my original nursing degree.

Life after leukemia and lymphoma
I have dealt with so many things that a normal 28-year-old wouldn’t. I’m facing hip replacements,knee replacements,memory loss,constant pain,and the fear that every bump I ever find in my body will be cancer. I’m afraid my family will always treat me as if I’m fragile and breakable,even though in my mind I am fiercely independent and strong. 

Cancer changed me for the better. I learned to be humble and accept humility. I learned that some friends will stick with you,and others won’t. 

And,I learned so much about myself. I learned that I WAS strong,even when I felt weaker than I had ever been. The amount of mental and spiritual strength that I gained is priceless. Facing the possibility of death in my early 20s caused me great emotional stress,but I will forever thank cancer for making me the person that I am today. 

To schedule an appointment at MD Anderson,please call 1-877-632-6789 or request an appointment online.

Cancerwise | Cancer blog from MD Anderson Cancer Center

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation

Methotrexate (MTX) is a widely used anticancer and antirheumatic drug that has been postulated to protect against metabolic risk factors associated with type 2 diabetes,although the mechanism remains unknown. MTX inhibits 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase (ATIC) and thereby slows the metabolism of 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranosyl-5′-monophosphate (ZMP) and its precursor AICAR,which is a pharmacological AMPK activator. We explored whether MTX promotes AMPK activation in cultured myotubes and isolated skeletal muscle. We found MTX markedly reduced the threshold for AICAR-induced AMPK activation and potentiated glucose uptake and lipid oxidation. Gene silencing of the MTX target ATIC activated AMPK and stimulated lipid oxidation in cultured myotubes. Furthermore,MTX activated AMPK in wild-type HEK-293 cells. These effects were abolished in skeletal muscle lacking the muscle-specific,ZMP-sensitive AMPK-3 subunit and in HEK-293 cells expressing a ZMP-insensitive mutant AMPK-2 subunit. Collectively,our findings underscore a role for AMPK as a direct molecular link between MTX and energy metabolism in skeletal muscle. Cotherapy with AICAR and MTX could represent a novel strategy to treat metabolic disorders and overcome current limitations of AICAR monotherapy.

Diabetes Journal publish ahead of print articles

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

Three-dimensional bioprinting:new horizon for cardiac surgery

Friedhelm Beyersdorf
Sep 1,2014;46:339-341
Editorial
Eur J Cardiothorac Surg:Most-Read Full-Text Articles

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

ICU Medical ConMed Stat2 Flow Controller:Class 1 Recall –Delivers Higher Flow Rate than Intended

Use of the affected product may cause serious adverse health consequences,including death.
MedWatch Safety Alert RSS Feed

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

QuickStats:Percentage of Adults Aged 18–59 Years Who Were Ever Tested for Human Immunodeficiency Virus (HIV),by Race and Hispanic Ethnicity — United States,National Health and Nutrition Examination Survey,2003–2006 to 2007–2010

Morbidity and Mortality Weekly Report (MMWR)

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

Developing an Incident Management System to Support Ebola Response — Liberia,July–August 2014

Morbidity and Mortality Weekly Report (MMWR)

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

Assured Brand Naproxen Sodium Tablets by Contract Packaging Resources,Inc.:Recall –Packaging Mix-Up

Risk of allergic reactions,from mild irritation or hives to serious reactions such as anaphylaxis that may be life-threatening.
MedWatch Safety Alert RSS Feed

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!

Coping with GVHD after my stem cell transplant

Harley731.jpgBy Harley Hudson

I decided to keep a diary of my stem cell transplant experience so it might help others in preparing for their stem cell transplants. You can read my previous entry here.
 
Just the words “graft-vs.-host disease”(GVHD) are enough to make stem cell transplant patients shiver. We’ve all heard the stories of the worst cases.

After everything I’d learned about stem cell transplants leading up to my own this past summer,I was afraid of developing GVHD even though my doctors told me the majority of patients actually don’t end up developing this condition.

And then it happened. Sixty-six days after I underwent a stem cell transplant to treat my chronic lymphocyctic leukemia (CLL),a rash appeared on my legs and arms. I was pretty sure it was GVHD. This was confirmed the following morning when one of my doctors,Issa Khouri,M.D.,and his team looked at my very red and splotchy legs and arms.

My GVHD treatment

Big deal,right? In truth,it wasn’t. Melanie and I were prepared for this. We were pretty sure of I had GVHD even before I visited the doctor. This was simply a small speed bump on the way to full recovery.
All we needed was the treatment plan so we could get rid of it in the least amount of time. I was prescribed a steroid cream and prednisone. A week later,the GVHD was under control.

The key was catching it early so that I could receive prompt treatment. I suppose it was the research we’d done before my transplant that gave us the peace of mind to simply accept that it was easily treatable. But,as an added precaution,I posted the finding on my Facebook page so all of my friends would know to pray. They responded in marvelous ways —and so did my GVHD.

What is GVHD?
GVHD occurs when the new cells from a transplant attacks not only the cancer but also the body.

GVHD can attack any organ or body tissue. The most common locations are the skin,mouth,gut,liver and lungs. GVHD also can attack joints,eyes or any other tissue. That is why it is very important to report all abnormalities,no matter how trivial they seem.

GVHD can be acute (usually occurring within 100 days of the transplant) or chronic. Symptoms of chronic GVHD can range from a temporary rash like mine to more chronic issues like joint problems,dry eyes,or symptoms similar to an autoimmune disorder.

The immune system doesn’t have a mechanism that allows it to naturally defend against GVHD. That’s why early detection and proper treatment are so important.

This also is partly why your care team performs daily blood draws following a stem cell transplant. The nurses are specially trained to work with transplant patients. They know what to look for. They ask questions. But it is the job of us,the patients,to be honest and aware of our own bodies.

GVHD is a serious matter,but the good news is the team at MD Anderson knows exactly how to treat it with great success. Personally,I would not go anywhere else in the world for treatment. As I look around,I see that people from around the world feel the same way.

Harley Hudson is a retired pastor,carpenter,electrician,plumber,assembler of road graders,furniture refinisher,janitor,graphic designer,English teacher,aircraft parts inspector,and college adjunct professor of writing,among other lesser career choices He and his wife live in Arkansas and have three daughters and nine grandchildren. Follow him on his personal blog,or read more Cancerwise posts by Harley Hudson.

Chronic lymphocytic leukemia (CLL) is one of the cancers MD Anderson is focusing on as part of our Moon Shots Program to dramatically reduce cancer deaths. Learn more about our CLL Moon Shot.

Cancerwise | Cancer blog from MD Anderson Cancer Center

Content is copyrighted by the respective owners.

Advertisement:
Looking for a rental home or apartment?
www.PutnamRenter.com

Buying or selling real estate in Putnam NY?
www.MovingToPutnam.com

Be Sociable,Share!